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iCRT 14

CAS No. 677331-12-3

iCRT 14( iCRT14 | iCRT-14 | iCRT 14 | Wnt inhibitor )

Catalog No. M18982 CAS No. 677331-12-3

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    iCRT 14
  • Note
    Research use only, not for human use.
  • Brief Description
    iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
  • Description
    iCRT14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    iCRT14 | iCRT-14 | iCRT 14 | Wnt inhibitor
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Wnt
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    677331-12-3
  • Formula Weight
    375.44
  • Molecular Formula
    C21H17N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 29 mg/mL; 77.24 mM
  • SMILES
    O=C4S\C(=C/c2cc(C)n(c1cccnc1)c2C)C(=O)N4c3ccccc3
  • Chemical Name
    5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gonsalves FC, et al. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63.
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