iCRT 14

CAS No. 677331-12-3

iCRT 14 ( iCRT14; iCRT-14; iCRT 14; Wnt inhibitor )

Catalog No. M18982 CAS No. 677331-12-3

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 60 In Stock
10MG 105 In Stock
25MG 176 In Stock
50MG 260 In Stock
100MG 386 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    iCRT 14
  • Note
    Research use only, not for human use.
  • Brief Description
    iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
  • Description
    iCRT14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM).
  • Synonyms
    iCRT14; iCRT-14; iCRT 14; Wnt inhibitor
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Wnt
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    677331-12-3
  • Formula Weight
    375.44
  • Molecular Formula
    C21H17N3O2S
  • Purity
    98%
  • Solubility
    DMSO : ≥ 29 mg/mL; 77.24 mM
  • SMILES
    O=C4S\C(=C/c2cc(C)n(c1cccnc1)c2C)C(=O)N4c3ccccc3
  • Chemical Name
    5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gonsalves FC, et al. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63.
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